Quinolizidine alkaloids from Sophora tonkinensis and their anti-inflammatory activities
LJ He, JS Liu, D Luo, YR Zheng, YB Zhang, GC Wang… - Fitoterapia, 2019 - Elsevier
Two new quinolizidine-based alkaloids (2 and 12), along with ten known ones (1, 3–11)
were isolated from the roots of S. tonkinensis. Their structures were determined by
spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction,
electronic circular dichroism analyses (ECD), and comparing with related literatures.
Compounds 1, 3–12 at non-toxic concentrations exhibited potent anti-inflammatory activities
according to in vitro and in vivo anti-inflammatory tests. Among them,(−)-anagyrine (4) …
were isolated from the roots of S. tonkinensis. Their structures were determined by
spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction,
electronic circular dichroism analyses (ECD), and comparing with related literatures.
Compounds 1, 3–12 at non-toxic concentrations exhibited potent anti-inflammatory activities
according to in vitro and in vivo anti-inflammatory tests. Among them,(−)-anagyrine (4) …
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